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Authors
Affiliations
1 Department of Pharmacology, Jogaiah Institute of Technology and Sciences, College of Pharmacy, IN
2 Jogaiah Institute of Technology and Sciences, College of Pharmacy, Kalagampudi, W.G, Andhra Pradesh, IN
3 Gogulakrishna College of Pharmacy, Sulurpet, Andhra Pradesh, IN
4 Srikrupa Institute of Pharmaceutical Sciences, Vil. Velkatta, Kondapak (Mdl), Dist. Medak, Siddipet, Andhra Pradesh - 502 277, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 2 (2012), Pagination: 64-69
Abstract
The Antidiabetic activity of fruits and seeds ethanolic extract of Luffa acutangula (Cucurbitaceae) was studied in a Streptozotocin {STZ) induced diabetic in rats. The acute toxicity and lethality (LD50) and the Phytochemicals analysis of the extract were also evaluated. The results showed that the extract (200 and 400 mg/kg) significantly (P<0.05) reduced fasting blood sugar of Streptozotocin diabetic rats in a dose-related manner, with maximum hypoglycemic effect at after 21 days. Acute toxicity and lethality test of the extract in rats gave an oral LD50 greater than 5 g/kg. It is clearly evident from the study that the streptozotocin administration caused the significant increase in the blood glucose level at 0 day (p<0.001). The 50% ethanolic extract of the fruits of Luffa acutangula showed the significant effect compared with the respective diabetic control group, decrease the blood glucose level at a dose of 200 mg/kg and 400 mg/kg (p<0.001), the standard drug glibenclamide also showed the significant decrease the blood glucose level after 21 days (241.33-105.33, p<0.001). Finally the 400 mg/kg and the standard drug showed the significant decrease in the blood glucose level after 21 days treatment (p<0.001). The findings indicate that the leaves of Luffa Acutangula may be beneficial as an Antidiabetic therapy.
Keywords
Streptozotocin, Luffa acutangula, Antidiabetic.
